Home › Obstructive Sleep Apnea › NCT06926036

Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

Who can join

Ages 18 to 60 · All sexes

Inclusion Criteria:

1. Right-handed, English-speaking adults, 18-60 years old who report normal hearing during sleep
2. Participants with suspected obstructive sleep apnea (OSA) (including those who have been diagnosed by a physician and those whose self-reported symptoms of OSA on the STOP-BANG questionnaire classify them as being "individuals with intermediate to high risk".
3. No report of any other sleep disorder besides OSA.
4. No report of any neurological or cardiometabolic diseases or disorders.
5. Not currently under active treatment for sleep apnea.
6. BMI ≤ 40.

About the study

This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake.

Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subsequently have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting.

What is being tested

• Wake training + TMR (behavioral)

Sponsor: Northwestern University · Participants: 18 · Started: Apr 3, 2025

Contact the study team

• Ken A Paller, PhD · Phone: 847-467-3370

Official record on ClinicalTrials.gov — NCT06926036

Locations in the U.S.

Conditions

• Obstructive Sleep Apnea

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.