MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes
RecruitingPhase 2
MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes (MITO Study)
Who can join
Ages 18 to 85 · All sexes
Full eligibility criteria
Inclusion Criteria: * 18 - 85 years of age * Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis * Able to give informed consent and follow 2-step command. * English Speaking Exclusion Criteria: * Unable to stand from chair without physical assistance from another person (able to use assistive device). * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg). * Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization) * History of head trauma or concussion within the past 6 months * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction or arrhythmia in the previous year * Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg * Pregnant or breastfeeding. * Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator
About the study
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. Preliminary data shows a single bout of ischemic conditioning or oral ingestion of an over-the-counter antioxidant supplement called MitoQ may improve vascular function and muscle activity in individuals post-stroke.
What is being tested
- Ischemic Conditioning (device)
- Antioxidant Supplement (dietary supplement)
Sponsor: Medical College of Wisconsin · Participants: 30 · Started: Jul 22, 2025
Contact the study team
- Jennifer Nguyen · Phone: 414-955-5713
- Alicen Whitaker-Hilbig, DPT, PhD · Phone: 414-955-5713
Official record on ClinicalTrials.gov — NCT06930638
Locations in the U.S.
| Wisconsin | Medical College of Wisconsin, Milwaukee |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.