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Losartan to Improve Outcomes After Multi-ligament Knee Injury

Who can join

Ages 18 to 40 · All sexes

Inclusion Criteria:

* Multi-ligament knee injury defined as a complete grade III injury of 2 or more ligaments
* At least one ligament surgically reconstructed or repaired
* Willingness to comply with the study protocol and assessments

Exclusion Criteria:

* Allergic to any active or inactive ingredient of losartan
* Pregnant, planning to become pregnant, or sexually active females choosing not to use effective means of contraception during the 30-day course of losartan
* Those at increased risk of losartan related side effects including those with severe renal insufficiency, hepatic disease, hypotension, and/or hyperkalemia
* Have a history of prior knee ligament surgery of the involved knee
* Undergoing staged surgical procedures in the treatment of MLKI
* Have a traumatic brain injury that limits their ability to participate in their postoperative care or any condition that would preclude the ability to comply with postoperative rehabilitation
* Have a concomitant injury or underwent a surgical procedure that will preclude the ability to perform range of motion exercises (i.e. surgery for extensor mechanism rupture or avulsion, vascular graft surgery)

About the study

Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events. These complex injuries involving disruption of 2 or more ligaments often coincide with injuries to arteries, nerves, tendons, menisci, and/or fractures and can be devastating events. MLKIs often require complex treatments nearly 2 in 5 patients suffer complications after surgery. Loss of knee range of motion is the most common complication and is associated with military separation. There are also long-term effects of motion loss, as the need for motion-restoring surgery after MLKI is associated with an increased risk of osteoarthritis within 5 years of surgery. A person's ability to perform both activities of daily living and higher demand physical activities is often impaired both in the short and long term. In fact, only 1 in 3 people return to high-level sport after MLKI. The purpose of this translational randomized clinical trial is to determine if a 30-day course of oral Losartan improves a person's ability to return to work or sport, range of motion and strength, and reduce knee inflammation in the first year after surgical treatment of an MLKI.

What is being tested

• losartan 25 mg (drug)
• Placebo capsule (other)

Sponsor: Brigham and Women's Hospital · Participants: 90 · Started: Oct 1, 2025

Contact the study team

• Cale Jacobs, PhD · Phone: 508-216-1145
• Molly Zgoda · Phone: 508-216-1145

Official record on ClinicalTrials.gov — NCT06933706

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.