Home › Colonic Polyps › NCT06937671
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
Recruiting
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Adult patient (age 18 years or older) * Polyp size of at least 20 mm * \- Morphology: Flat or superficially raised polyp morphology (i.e., Paris classification 1s, 0-IIa or 0-IIb, or a combination of the above) Exclusion Criteria: * Polyps with previous failed resection attempts or polyp recurrence * Suspected deep submucosal invasion on endoscopic assessment of surface mucosal pit pattern (Kudo V or NICE 3 pattern) or histologically confirmed malignancy (invasive adenocarcinoma) * Polyps with nodules too large (\>1-1.5cm) for the use of a cold snare * Inflammatory bowel disease
About the study
The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps.
Participants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.
What is being tested
- Cold EMR (procedure)
- Hybrid EMR (procedure)
Sponsor: The Cleveland Clinic · Participants: 194 · Started: May 1, 2025
Contact the study team
- Akram Ahmad, M.D. · Phone: 954-659-5000
- Michael Nicolas, B.S. · Phone: 9546596213
Official record on ClinicalTrials.gov — NCT06937671
Locations in the U.S.
| Florida | Cleveland Clinic Weston, Weston |
| Ohio | Cleveland Clinic, Cleveland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.