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Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged

Wound Healing Outcomes in Aged Extraction Patient With Platelet Rich Fibrinogen

Who can join

Ages 14 to 80 · All sexes

Inclusion Criteria:

* Patient at University of Nebraska Medical Center (UNMC) College of Dentistry
* Requires extraction of posterior tooth
* Able and willing to provide consent/assent

Exclusion Criteria:

* Systemic conditions that delay wound healing
* Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy

About the study

The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.

What is being tested

• Platelet-rich fibrin (PRF) (procedure)

Sponsor: University of Nebraska · Participants: 12 · Started: May 1, 2025

Contact the study team

• Amy C Killeen, DDS, MS · Phone: 402-472-7848

Official record on ClinicalTrials.gov — NCT06943846

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.