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Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis

RecruitingPhase 2

A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase II Platform Study to Assess the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis

Who can join

Ages 18 to 100 · All sexes

Full eligibility criteria
Key Inclusion Criteria of the master protocol:

* Able and willing to sign the informed consent (IC)
* Patients with a diagnosis of AD and onset of disease for at least 1 year
* Moderate to severe AD

Key Exclusion Criteria of the master protocol:

* Participants with a clinically significant medical condition or infectious disease (specified in sub-protocol)
* Participants with clinically significant abnormal hematology, clinical chemistry, or urine test results or clinically significant abnormal ECG
* Participant with any other active inflammatory skin disease
* Participants with any chronic, uncontrolled medical condition, which would put the participant at increased risk during the study (e.g., uncontrolled: diabetes, hypertension)
* Participants with any clinically unstable disease states that would likely require systemic corticosteroids (e.g., uncontrolled asthma)

Additional inclusion and exclusion criteria may apply depending on the intervention specific requirements

About the study

This trial is designed to evaluate multiple compounds in participants with moderate to severe atopic dermatitis (AD).

What is being tested

Sponsor: Novartis Pharmaceuticals · Participants: 224 · Started: May 16, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06947993

Locations in the U.S.

AlabamaNovartis Investigative Site, Birmingham
Novartis Investigative Site, Birmingham
ArkansasNovartis Investigative Site, Fort Smith
CaliforniaNovartis Investigative Site, Fountain Valley
Novartis Investigative Site, Los Angeles
Novartis Investigative Site, Sacramento
Novartis Investigative Site, Santa Ana
Novartis Investigative Site, Santa Monica
District of ColumbiaNovartis Investigative Site, Washington D.C.
FloridaNovartis Investigative Site, Miami
Novartis Investigative Site, St. Petersburg
GeorgiaNovartis Investigative Site, Atlanta
Novartis Investigative Site, Macon
KentuckyNovartis Investigative Site, Louisville
MassachusettsNovartis Investigative Site, Brighton
MichiganNovartis Investigative Site, Troy
MissouriNovartis Investigative Site, Saint Joseph
New HampshireNovartis Investigative Site, Portsmouth
New YorkNovartis Investigative Site, Brooklyn
TexasNovartis Investigative Site, Arlington
Novartis Investigative Site, Cypress
Novartis Investigative Site, Dallas
Novartis Investigative Site, Houston
Novartis Investigative Site, San Antonio

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.