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Acute Effects of THC in Older Adult

Who can join

Ages 21 and older · All sexes · Healthy volunteers welcome

* Ability to provide informed consent
* No history (current or past) of unstable or serious medical, neurological or psychiatric conditions.
* High school education or greater
* No positive pregnancy test and/or lactation/ planning to nurse while in this study
* English speaking

About the study

The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.

What is being tested

• Delta-9-THC Low Dose (drug)
• Placebo (drug)
• Delta-9-THC Medium Dose (drug)

Sponsor: Yale University · Participants: 60 · Started: Jun 6, 2025

Contact the study team

• Deepak C D'Souza · Phone: 203-932-5711

Official record on ClinicalTrials.gov — NCT06948136

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.