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Investigating Periprosthetic Fracture Cultures in Arthroplasty

Investigating Periprosthetic Fracture Culture Positivity in Patients With Hip and Knee Arthroplasties

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adult patients (\>18 years old) with periprosthetic fractures around primary or revision hip or knee arthroplasty
* Patients requiring operative management for these fractures (fixation or revision arthroplasty)
* Patients presenting to the University of Chicago Medical Center during two (2) year period (October 2025 to October 2027)

Exclusion Criteria:

* Patients undergoing non-operative management for periprosthetic fractures
* Any documented or reported history of past prosthetic joint infection of the involved joint
* Sinus tract at the time of presentation at the involved joint

About the study

This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment decisions difficult. By studying how often infections are found through lab tests and identifying factors that predict infection, the investigators hope to create better ways to diagnose and care for these patients.

What is being tested

• Not applicable- observational study (other)

Sponsor: University of Chicago · Participants: 200 · Started: Oct 1, 2025

Contact the study team

• Malik J Scott, BA · Phone: 773-834-0822

Official record on ClinicalTrials.gov — NCT06952738

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.