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Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

Site Inclusion Criteria:

• UCHealth or Intermountain Health outpatient physical therapy clinic

Patient Inclusion Criteria:

* Underwent primary unilateral TKA
* Attended outpatient rehabilitation at a participating clinic within 5 days after TKA
* Attended at least 3 total outpatient physical therapy visits in total

Exclusion Criteria:

Patient Exclusion Criteria:

* NMES Contraindications \[Patients with implanted cardiovascular cardiovertedefibrillator (ICD), active cancer, post-operative diagnosed deep vein thrombosis (DVT) in involved lower extremity\]
* Previous lower extremity arthroplasty less than 12 weeks prior to scheduled TKA surgical date

About the study

Patients experience dramatic quadriceps strength loss after total knee replacement, which contributes to persistent weakness and reduced long-term function after surgery. Neuromuscular electrical stimulation (NMES) reduces quadriceps weakness and improves patient function after knee replacement, but it is drastically underused in rehabilitation practice. This randomized trial will examine the effectiveness and feasibility of a comprehensive strategy for implementing neuromuscular electrical stimulation after knee replacement in two large healthcare organizations.

What is being tested

• NMES (procedure)
• Usual Care (other)

Sponsor: University of Colorado, Denver · Participants: 3,250 · Started: May 12, 2025

Contact the study team

• Maggie Givan, MA · Phone: 719.251.7533

Official record on ClinicalTrials.gov — NCT06953375

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.