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The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress

Who can join

Ages 18 to 45 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Healthy volunteer
* Any race
* Estimated glomerular filtration rate greater than 90 ml/min/1.73m2
* Urine albumin/creatinine ratio less than 30mg/g
* Nonsmoker
* No regular dietary supplements, particularly vitamin B3
* Physically fit, defined as having a VO2 max of between 35 and 60mL/kg/min

Exclusion Criteria:

* Medical condition preventing safe participation in exercise during heat
* Allergy to Vitamin B3
* Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications

About the study

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are:

* How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

What is being tested

• Vitamin B3 (dietary supplement)

Sponsor: Beth Israel Deaconess Medical Center · Participants: 28 · Started: Jan 26, 2026

Contact the study team

• Nathan H Raines, MD MPH · Phone: 703-927-0992

Official record on ClinicalTrials.gov — NCT06983730

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.