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Early Versus Late Endoscopic Stenting for Refractory Benign Esophageal Strictures
Recruiting
Early Versus Late Endoscopic Temporary Stenting for Management of Refractory Benign Esophageal Strictures
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Able to give informed and written consent. * Able to keep follow up appointments as per protocol (minimum 2 years). * Biopsy proven benign esophageal stricture. * Dysphagia (grade 2 and above). * Fit to undergo upper GI endoscopy. * Documented esophageal stricture with a luminal diameter \<14 mm at index endoscopy. Exclusion Criteria: * Minimal dysphagia (grade 0-1) * Neuromuscular dysphagia (such as achalasia, oro-pharyngeal dysphagia post-stroke, crico-pharyngeal bar, Zenker diverticulum etc.) * Pregnant or planning to be pregnant during the study period. * Malignant or indeterminate esophageal stricture. * Actively receiving radiation therapy. * Persistent associated active esophagitis that has not yet healed. * Esophageal strictures associated with fistula/leaks/current or prior perforation. * Eosinophilic esophagitis. * Associated esophageal varices. * No other malignancy limiting life expectancy. * Patients in whom placing esophageal stents is not possible/contraindicated (such as high cervical esophageal strictures, active bleeding, metal allergy, tortuous esophagus, pseudodiverticulum with stricture). * Previous esophageal stent tried over 2 months ago * Significant comorbidities making patient high risk for upper GI endoscopy. * Unable to give informed consent. * Cannot keep follow up appointments as per protocol. * Procedures and stents not covered by patient's insurance. * Patients who, after comprehensive discussion and explanation of both the early-stent and late-stent approaches, choose to proceed with a specific approach and decline participation in randomization.
About the study
This project is being done to compare two current treatment clinical options for management of RBES: 1) Frequent dilations followed by temporary esophageal stent placement if dilations fail, or 2) Early stent placement followed by dilations
What is being tested
- Fully covered self-expandable metal esophageal stent (device)
Sponsor: Medical College of Wisconsin · Participants: 20 · Started: Oct 14, 2025
Contact the study team
Official record on ClinicalTrials.gov — NCT06991049
Locations in the U.S.
| Wisconsin | Froedtert Hospital, Milwaukee |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.