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Sodium in the Skin and Atopic Dermatitis

Who can join

Ages 50 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Ages 50 years and above
* Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy).

Exclusion Criteria:

* History of autoimmune disease.
* Cardiac events in the last six months.
* Impaired function of the liver or kidneys (glomerular filtration rate \<60ml/min).
* Current use of medications that influence sodium excretion (e.g. thiazide diuretics, SGLT2 inhibitors and spironolactone), and/or chemotherapy or antibiotic treatment.
* Currently receiving phototherapy or taking systemic medications for atopic dermatitis including cyclosporine, methotrexate, or other broad immunosuppressive medications.

(Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the criteria for severe disease.)

About the study

The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above.

The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time.

Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.

Sponsor: University of California, San Francisco · Participants: 90 · Started: May 12, 2025

Contact the study team

• Jie Zhu, MD · Phone: 415-502-0433
• Katrina Abuabara, MD · Phone: 415-514-9769

Official record on ClinicalTrials.gov — NCT06998446

Locations in the U.S.

Conditions

• Eczema
• Atopic Dermatitis (Eczema)

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.