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Quadriceps Motor Unit Adaptation to Simulated Knee Injury

Who can join

Ages 18 to 30 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Age 18-30 years
2. Physically active (Tegner ≥ 5)
3. No prior lower-limb surgery or major injury

Exclusion Criteria:

1. Lower limb surgery or significant injury in past 2 years
2. Cardiopulmonary, neurological, or psychiatric disorders
3. Needle/electrical stimulation anxiety
4. Medications affecting neuromuscular or psychological function
5. Pregnancy
6. Allergic to lidocaine
7. Inability to elicit Hoffmann reflex

About the study

This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.

What is being tested

• Joint Effusion via 60 mL Sterile Saline (device)
• Intra-articular Lidocaine (drug)
• Sham injection (other)

Sponsor: University of Central Florida · Participants: 45 · Started: Aug 1, 2026

Contact the study team

• Grant Norte, Ph.D. · Phone: 407-823-3188

Official record on ClinicalTrials.gov — NCT06999057

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.