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Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Critically Ill Adults: A Cluster-Randomized, Cluster-Crossover Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Admitted to intensive care unit (ICU)
* Age 18 years or older
* Requiring invasive mechanical ventilation for at least 24 hours
* Pass spontaneous breathing trial screen criteria

Exclusion Criteria:

* Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results
* Do not intubate (DNI) order
* Presence of tracheostomy
* Pregnancy
* Known prisoner
* Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures
* Enrolled in another clinical trial that impacts ventilator weaning or liberation

About the study

For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.

What is being tested

• Pressure Support Ventilation (PSV) (other)
• Automatic tube compensation (ATC) (other)

Sponsor: Rush University Medical Center · Participants: 880 · Started: Jun 1, 2025

Contact the study team

• Jie Li, PhD · Phone: 312-563-4643

Official record on ClinicalTrials.gov — NCT07005505

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.