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A Study of Time-Restricted Eating in Childhood Cancer Survivors

Recruiting

Decreasing Cardiometabolic Risk in Childhood Cancer Survivors: The STRENGTH (Survivors Engaged in Time-Restricted EatiNG After THerapy) Study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Enrolled in the Childhood Cancer Survivor Study (a cohort of 5+ year survivors of childhood cancer diagnosed at age \< 21 between 1970-1999 at 31 participating institutions in North America)
* Are ≥18 years old
* Self-reported body mass index ≥ 25 kg/m2
* Are not pregnant or do not intend to become pregnant in the next year
* Stable weight over the past 3 months (+/- 10 pounds)
* If on oral medication for insulin resistance (ie, metformin), elevated blood pressure, or dyslipidemia, medication dose must be stable (ie, unchanged \> 3 months)
* Have internet access (can be via smartphone or computer). If neither device is available, the study can loan participants a Wi-Fi enabled device.

Exclusion Criteria:

* Do not reside in the United States
* Do not speak English
* Eating window \< 12 hours per 24-hour day
* On insulin or GLP-1 agonist
* Diagnosis of type 1 diabetes mellitus
* Enrolled in a formal weight management program or other weight loss trial
* History of an eating disorder

About the study

This study will look at whether motivational sessions (including regular calls with a trained health coach) in combination with time-restricted eating (TRE) is an effective way to achieve weight loss and lower cardiometabolic risk in adult survivors of childhood cancer. The researchers will look at how effective this intervention is compared to the usual approach, which is to review educational materials and measure weight once a month. This study will not provide treatment for any disease or cancer.

What is being tested

Children's Oncology Group Heart Health Link (other)
Monthly weights (other)
Fasting (other)
Calls (other)
Participant Questionnaires (other)
Dried blood spot (other)

Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 300 · Started: May 27, 2025

Contact the study team

Danielle Friedman, MD · Phone: 1-833-MSK-KIDS
Chaya Moskowitz, PhD · Phone: 646-227-3607

Official record on ClinicalTrials.gov — NCT07009288

Locations in the U.S.

New York	Hunter College, New York (Not yet recruiting) Memorial Sloan Kettering Cancer Center, New York
Tennessee	St. Jude Children's Research Hospital (Data Collection Only), Memphis
Washington	Fred Hutchinson Cancer Research Center (Data Collection Only), Seattle (Not yet recruiting)

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.