Home › Obsessive-Compulsive Disorder › NCT07011901
Precision Analytic Research Methods in OCD
Dissecting Neurocognitive Components of Compulsivity Using Computational Modeling and EEG
Who can join
Ages 18 to 55 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: Participants must be: * between the ages 18-55 years old * English-speaking * right-handed * able to provide consent Exclusion Criteria: Individuals diagnosed with OCD will be excluded if: * they meet diagnostic criteria for certain other psychiatric disorders * are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe * if it is unsafe for them to participate in research Healthy control participants will be excluded if: * they have a current psychiatric disorder * a lifetime history of certain psychiatric disorders * are taking psychiatric medication or have in the past * have a parent or sibling who has been diagnosed with OCD * if it is unsafe for them to participate in research
About the study
Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.
What is being tested
- Exposure and Response Prevention (behavioral)
Sponsor: Icahn School of Medicine at Mount Sinai · Participants: 100 · Started: Jul 9, 2025
Contact the study team
- Amy Rapp, Ph.D. · Phone: 212-241-5288
Official record on ClinicalTrials.gov — NCT07011901
Locations in the U.S.
| New York | Icahn School of Medicine at Mount Sinai, New York |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.