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Burning Mouth Syndrome: Symptoms and Management

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Have buring mouth syndrome or experience oral burn
* Live in the United States
* At least 18 years old
* Having been diagnosed or suspected diagnosis of burning mouth syndrome or suffer from chronic oral burn without any identifiable causative lesion
* No tongue or cheek piercings
* No history of cancer
* No recent or scheduled dental treatment
* No history of gum disease
* No aversions to mint or hop extracts

Exclusion Criteria:

* Have recently undergone dental treatment in the last three months or have plans to undergo dental treatment (e.g., fillings, crowns, root canals, extractions, or other dental procedures) in the coming month.
* Have started any new treatments for BMS in the last 3 months or have plans to start new treatments in the coming month.

About the study

This research study aims to evaluate how an oral cooling spray, currently a commercial dietary supplement, impacts symptoms associated with burning mouth syndrome (BMS). This study will examine symptoms, frequency, and severity, along with other related side effects of BMS on food intake, enjoyment, and quality of life.

What is being tested

• Oral cooling spray (dietary supplement)

Sponsor: University of Massachusetts, Amherst · Participants: 50 · Started: Jun 11, 2025

Contact the study team

• Alissa Nolden, PhD · Phone: 413-577-0113

Official record on ClinicalTrials.gov — NCT07016555

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.