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Stable Isotopes- Adults With Obesity

Assessing Metabolic Health With Stable Isotope Tracer Techniques in Adults With Obesity

Who can join

Ages 19 to 59 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* ages 19-59
* Obese \>/= 30 kg/m\^2 and \>/= 102 cm for males and \>/= 88 cm for females
* Godin Leisure-time or exercise questionnaire \<14 units

Exclusion Criteria:

1. Pregnant or become pregnant
2. Any known food allergies
3. Smoker
4. Are physically active
5. Have any known metabolic diseases
6. Have been weight unstable within the last 6 months (lost or gained \>10% of body mass)
7. Non eumenorrheic or on a hormonal birth control

About the study

In a crossover design, 8 participants will receive caloric drinks containing stable isotopes. In one arm of the study, participants will consume 6 hourly drinks containing two stable isotopes. Repeated blood, breath, urine, and muscle biopsies will be taken. In the second arm, participants will consume 1 drink containing 75g glucose, labeled with two stable isotopes of glucose. Periodic blood and breath will be taken over three hours.

What is being tested

• Indispensable Amino Acid Oxidation (procedure)
• Stable Isotope Oral Glucose Tolerance Test (procedure)

Sponsor: University of Illinois at Urbana-Champaign · Participants: 8 · Started: Sep 12, 2025

Contact the study team

• Nicholas Burd (Associate Professor), PhD · Phone: 2172440970
• Gena L Irwin (Research Assistant), M.S · Phone: 3608883281

Official record on ClinicalTrials.gov — NCT07020741

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.