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Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).

Brachytherapy Fractionation Individualized by Treatment Feasibility in Cervical Cancer: Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Histologically documented malignancy of the cervix and planned to receive brachytherapy as part of definitive treatment.
* ECOG performance status of 0-2
* Age ≥ 18 years old.
* Ability to understand and the willingness to provide written informed consent.

Exclusion Criteria:

* Contraindication to receiving radiotherapy as determined by treating radiation oncologist.
* Contraindication to receiving MRI.
* Prior radiation to the pelvis \> 3 months ago
* Age \< 18 years old.
* Pregnant or breast-feeding

About the study

This is a prospective non-randomized clinical trial to evaluate the feasibility of 3 fraction versus a standard 4 fraction high dose rate brachytherapy regimen in patients with locally advanced cervical cancer.

What is being tested

• 3-Fraction HDR Brachytherapy (radiation)
• 4-Fraction HDR Brachytherapy (radiation)

Sponsor: Stanford University · Participants: 41 · Started: Jun 3, 2025

Contact the study team

• Alyssa Yauger · Phone: (650) 498-5271
• Jillian Skerchak · Phone: (650) 721-4072

Official record on ClinicalTrials.gov — NCT07022470

Locations in the U.S.

Conditions

• Cervical Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.