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Improving Medication Management in World Trade Center Responders

Promoting Healthy Aging Among WTC Responders: Frailty Trajectories And Intervention Strategies

Who can join

Ages 50 and older · All sexes

Inclusion Criteria:

* A WTC responder already enrolled in the "Promoting Healthy Aging Among WTC Responders: Frailty Trajectories and Intervention Strategies" study cohort
* aged 50 years or older, and
* taking one of the five medication classes:

  * proton pump inhibitors (PPIs),
  * benzodiazepine (BZs) and
  * non-benzodiazepine sedative hypnotics ("Z-drugs"),
  * first-generation antihistamines (FGA), and
  * skeletal muscle relaxants (SMR).

Exclusion Criteria:

* None

About the study

By 2030, the majority of World Trade Center (WTC) rescue and recovery workers (responders) will be aged 65 and over and at risk for aging-related conditions and consequences including the concurrent use of five or more medications (i.e., polypharmacy). The purpose of this research study is to investigate an educational approach targeting polypharmacy through de-prescribing unnecessary and burdensome medications via the support of informed discussions between WTC responders and their prescribing physicians.

What is being tested

• Educational brochure for deprescribing (other)

Sponsor: Icahn School of Medicine at Mount Sinai · Participants: 50 · Started: Apr 8, 2025

Contact the study team

• Patricia Kim · Phone: 212-241-9370

Official record on ClinicalTrials.gov — NCT07022990

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.