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Prospective Study of EXErcise Regimens After Treatment for Breast Cancer for Hypertrophy and Conditioning

EXERT-BCHC: Prospective Study of EXErcise Regimens After Treatment for Breast Cancer for Hypertrophy and Conditioning

Who can join

Ages 20 to 89 · Women

Inclusion Criteria:

1. Age 20-89 years
2. Women prescribed exercise as a Standard of Care
3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy.
5. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
6. Women with \> 6 months of resistance training experience under expert guidance by a CSCS

Exclusion Criteria:

1. Any current treatment with cytotoxic chemotherapy for breast cancer
2. Inability to safely engage in group sessions of resistance training as deemed by study Pl
3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by Pl to be unsafe to engage in resistance training
4. Beta blocker or GLP-1 inhibitor medications
5. Pregnant women
6. Males

About the study

This study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. The study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 cluster sets and double training) to assess changes in VO2 max, muscle mass, and fat mass.

What is being tested

• 6-12-25 Training Regimen (other)
• 8x8 Training Regimen (other)
• 5/5/5 Cluster Set Training Regimen (other)
• Double Training Regimen (other)

Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Participants: 15 · Started: May 21, 2025

Contact the study team

• Clinical Trials Contact · Phone: 412-330-6151

Official record on ClinicalTrials.gov — NCT07023887

Locations in the U.S.

Conditions

• Cancer (all types)
• Breast Cancer

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.