Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Inclusion Criteria:

* Elevated fasting TGs and RC
* Elevated nonfasting TGs and RC
* Part A only: Fasting LDL-C ≥ 50 mg/dL (≥ 1.29 mmol/L) and ≤ 130 mg/dL (≤ 3.36 mmol/L)
* Willingness to provide informed consent and comply with the intervention and all study assessments
* Stable diet for a minimum of 3 months prior to screening and with no plans to change during screening or trial participation
* Stable drug regimen (if relevant) prior to screening visit and no planned changes after enrollment; Part B only: adjustment of lipid-lowering therapy during the diet/lifestyle run-in period is permitted

Exclusion Criteria:

* Acute or chronic liver disease
* Part A only: TG concentration ≥880mg/dl; Part B only: TG concentration ≥2000 mg/dL
* History of type 1 diabetes mellitus or history of diabetic ketoacidosis
* Newly diagnosed T2DM
* Participants with known active hepatitis A, B, or C
* Uncontrolled hypothyroidism

  * Part B only: recent history of active pancreatitis

    * Part B only: genetically confirmed Familial Chylomicronemia Syndrome (FCS) diagnosis due to biallelic loss of function mutations in LPL or GPIHBP1
    * Part B only: use of ANGPTL3 and ApoC-III inhibitors
* Any condition that prevents the participant from complying with study procedures