Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity
Upper Body Subcutaneous Adipose Tissue Outflow Response to a Meal
Who can join
Ages 18 to 55 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: • All women must be premenopausal Exclusion Criteria: * Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements) * Diabetes, history of cardiovascular disease * Allergy to lidocaine * Post-menopausal women * Pregnant
About the study
The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.
What is being tested
- Meal Study (diagnostic test)
Sponsor: Mayo Clinic · Participants: 20 · Started: May 5, 2026
Contact the study team
- Kelli A. Lytle, Ph.D. · Phone: 507-255-1488
Official record on ClinicalTrials.gov — NCT07031297
Locations in the U.S.
| Minnesota | Mayo Clinic in Rochester, Rochester |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.