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Betadine vs Sterile Water for Periurethral Preparation

Betadine vs Sterile Water for Periurethral Preparation Prior to Straight Catherization in the Clinic Setting: A Randomized Controlled Trial

Who can join

Ages 18 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

* Aged 18+
* Patient undergoing in office straight catherization

Exclusion Criteria:

* History of culture proven recurrent urinary tract infection (2 in any 6-month period or 3 in any 12-month period)
* Urine Analysis with +Nitrites
* Catherization for any reason in the last 4 weeks
* History of Iodine allergy
* Patients unable to speak English
* Patient does not have the capacity to consent
* 2-3rd trimester pregnancy

About the study

The purpose of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water (water that has been treated to remove bacteria and living organisms) vs Betadine also known as Povidone-Iodine (a medical grade cleaning solution) changes the rates of bacteria in the urine after a temporary catheter, or draining tube, is placed into the bladder. Chemical antiseptics, including Betadine, are the current standard of care. An additional goal of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water vs betadine changes the amount of discomfort or pain patients experience with placement of a temporary catheter, or draining tube, in the bladder.

What is being tested

• Povidone-Iodine (drug)
• Sterile water (drug)

Sponsor: University of Louisville · Participants: 148 · Started: Jun 30, 2025

Contact the study team

• Kathryn C Seymour, MD · Phone: 502-588-7660
• Ankita Gupta, MD, MPH · Phone: 502-588-7660

Official record on ClinicalTrials.gov — NCT07044726

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.