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Role of Mitochondrial Bioenergetics in Resilience for Gynecologic Cancer

RecruitingObservational study

The Role of Mitochondrial Bioenergetics in Resilience in Older Adults With Gynecologic Cancer Receiving Cancer Reductive Treatment

Who can join

Ages 50 and older · Women

Full eligibility criteria
Inclusion Criteria:

* Ability to understand and willingness to sign an IRB-approved informed consent
* Age ≥50 years at the time of enrollment
* Newly diagnosed or suspected FIGO Stage II-IV ovarian/primary peritoneal/fallopian tube carcinoma of any histological subtype OR FIGO Stage II-IV endometrial carcinoma of any histological subtype
* Planned, standard of care treatment consisting of neoadjuvant chemotherapy, tumor reduction surgery, and adjuvant chemotherapy OR tumor reduction surgery with adjuvant chemotherapy
* Ability to read and understand the English language

Exclusion Criteria:

* Previously treated for ovarian or endometrial cancer
* History of brain metastases, whole brain irradiation, poorly controlled psychiatric disorders defined by hospitalization within the last 3 months for psychiatric diagnoses, traumatic brain injury, cerebrovascular event, or dementia
* Currently taking anti-amyloid agents, cholinesterase inhibitors, or glutamate regulator
* Documented physical or psychological comorbidity that would limit participant's ability to understand or comply with study procedures for the entire length of the study

About the study

The purpose of this research study is to see if patients with endometrial and ovarian cancer are willing to complete physical and cognitive assessments before treatment and again after treatment has ended.

What is being tested

Sponsor: Wake Forest University Health Sciences · Participants: 30 · Started: Mar 10, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07046936

Locations in the U.S.

North CarolinaAtrium Health Levine Cancer, Charlotte
Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.