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Pre-Op MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma

Prospective Evaluation of Pre-Operative MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Adults ≥ 18 years of age.
2. Participants being considered for TORS for HPV+ tonsillar SCC.

Exclusion Criteria:

1. Participants \< 18 years of age.
2. Participants who cannot provide informed consent.
3. Participants who do not wish to participate.
4. Vulnerable populations, including but not limited to cognitively impaired persons, pregnant women, and students or house staff under the direct supervision of the investigator.
5. Participants in whom MRI is contraindicated.

About the study

This prospective research study aims to see if pre-operative MRI can predict the margin status after transoral robotic surgery (TORS) for human papillomavirus positive (HPV+) tonsillar squamous cell carcinoma (SCC). The pre-operative MRI will have a standard MR neck without and with contrast, with added axial T2 weighted sequence and T2 SPACE sequence through the tonsils. Three neuroradiologists will grade the thickness of the pharyngeal constrictor muscle (the muscle that surrounds the tonsils) on a five-point scale. The study will determine if the pre-operative MRI grading will correlate with positive, insecure (\<1mm), or secure (\>1mm) margin during TORS surgery for your HPV+ tonsillar SCC.

What is being tested

• Transoral robotic surgery+MRI (procedure)

Sponsor: Case Comprehensive Cancer Center · Participants: 30 · Started: Nov 26, 2025

Contact the study team

• Jonathan Lee, MD · Phone: 216-445-9390

Official record on ClinicalTrials.gov — NCT07060261

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.