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Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

The Effect of Ketone Monoester Supplementation and High Altitude on Exercising Cerebral Blood Flow

Who can join

Ages 18 to 35 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

\- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California

Exclusion Criteria:

* BMI \> 30
* No prescribed medications (oral contraceptives excluded)
* History of smoking
* Currently following a ketogenic diet or consuming exogenous ketogenic supplements
* History of heart, lung, blood vessel, or kidney disease
* Currently pregnant

About the study

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

What is being tested

• Ketone Monoester (KME) (dietary supplement)
• Placebo (dietary supplement)

Sponsor: McMaster University · Participants: 14 · Started: May 28, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07063732

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.