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Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

Objective Grading of Intraocular Inflammation in Uveitis Using Optical Coherence Tomography

Who can join

Ages 5 to 85 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
2. Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
3. Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.

Exclusion Criteria:

1. Inability to give informed consent.
2. Inability to maintain stable fixation for OCT imaging.
3. Inability to commit to required visits to complete the study.
4. Pregnancy and breastfeeding.

About the study

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Sponsor: Oregon Health and Science University · Participants: 125 · Started: Sep 1, 2024

Contact the study team

• Humberto Martinez, COT, MBA · Phone: 503-494-7712
• Denzil Romfh, OD · Phone: 503-494-4351

Official record on ClinicalTrials.gov — NCT07065747

Locations in the U.S.

Conditions

• Juvenile Arthritis
• Sarcoidosis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.