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Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

Who can join

Ages 21 to 70 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Adults who are relatively healthy and aged 21-70 years.
* Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
* Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion Criteria:

* Participated in previous acute stress studies that included a similar stress induction.
* Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
* Self-reported current pregnancy.
* Self-reported current use of illicit substances (other than cannabis).
* Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
* Students of the principal researcher

About the study

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

What is being tested

• Stress Intervention (other)

Sponsor: University of Minnesota · Participants: 125 · Started: Jun 16, 2025

Contact the study team

• Stress and Resilience Research Labs · Phone: 2187268623

Official record on ClinicalTrials.gov — NCT07069478

Locations in the U.S.

Conditions

• Acute Traumatic Stress Disorders

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.