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Ropivacaine and Fentanyl for Labor Epidural Initiation

Determination of the 90% Effective Volume (ED90) of Epidural 0.1% Ropivacaine and Fentanyl for Labor Analgesia Initiation in Patients Receiving a Dural-Puncture Epidural Technique

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Patients with singleton vertex pregnancies in active labor (latent or spontaneous labor or after induction of labor)
* Cervical dilatation between 2 and 7 cm
* Requesting neuraxial labor analgesia
* Age 18 or older

Exclusion Criteria:

* Significant obstetric disease (e.g., pre-eclampsia, major cardiac disease)
* Chronic pain or chronic opioid use
* BMI ≥ 50
* Multiple gestations
* Allergy or anaphylaxis to local anesthetic
* Fetal compromise or non-reassuring fetal trace
* Age under 18
* Inability to speak and understand English or Spanish

About the study

This study is being done to determine the most effective dose of medicine to use to initially provide effective pain relief within the first 30 minutes of receiving an epidural for pain labor during labor. The study team will also study any side effects related to the epidural medication and patients' satisfaction with the quality of pain relief after receiving the epidural.

What is being tested

• Ropivacaine + Fentanyl (drug)

Sponsor: University of California, San Francisco · Participants: 50 · Started: Oct 24, 2025

Contact the study team

• Alexander Butwick, MBBS, FRCA, MS · Phone: 415-514-3757

Official record on ClinicalTrials.gov — NCT07076368

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.