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Quantitative Versus qUAlitative NeuromoniToring of neUroMuscular Block for Non-cardiothoracic Surgery

Quantitative Versus qUAlitative NeuromoniToring of neUroMuscular Block for Non-cardiothoracic Surgery (The QUANTUM Trial): Single-center Cluster Randomized Multiple Crossover Trial

Who can join

Ages 18 and older · All sexes

Inclusion criteria:

* Patient age ≥ 18 years old;
* General anesthesia with endotracheal intubation;
* Neuromuscular block with rocuronium.

Exclusion criteria:

* Intubation before induction of anesthesia;
* Critically ill patients admitted from the ICU;
* Emergency cases;
* Non-intubated patients;
* Patients who will not be paralyzed through the surgery (spine).
* Patients with an implanted electronic device (e.g. cardiac pacemaker)
* Patients with allergies to adhesive
* Patients with pre-existing neuromuscular disease (e.g. Myasthenia Gravis)

About the study

The purpose of this study is to assess the effect of quantitative block monitoring versus less expensive qualitative monitoring treatment effects on the lowest SpO2/FiO2 ratio in the PACU. The results will be incorporated into an enhanced recovery pathway for surgical patients.

What is being tested

• Quantitative monitoring (device)
• Qualitative monitoring (other)

Sponsor: The University of Texas Health Science Center, Houston · Participants: 1,032 · Started: Sep 22, 2025

Contact the study team

• Mehmet Turan, MD · Phone: (713) 500-6251
• Mohammad Khudirat · Phone: (713) 500-5558

Official record on ClinicalTrials.gov — NCT07084363

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.