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Comparison of Outcomes of Management of Bowel Obstruction
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Adults ≥18 years of age recruited from UWMC * Patients presenting to surgical services through the Emergency Department, diagnosis of SBO, consulted by surgeon, and an urgent or emergency operation is deemed not necessary by surgeon. * Diagnosis of aSBO is established by; 1. CT findings consistent with diagnosis of SBO; and 2. signs and symptoms consistent with SBO; and 3. Adhesions from prior abdominopelvic surgery are the likely cause of SBO (absence of incarcerated hernia, internal hernia, masses, fistula, stricture, volvulus, acute episode of inflammatory bowel disease (IBD) flare, etc.). * Ability to provide written or electronic informed consent in English and answer teach-back questions Exclusion Criteria: * Signs and symptoms of peritonitis with emergency operation planned * Planned urgent operation within the next 12 hours * Allergy to dexamethasone * Surgery within prior 6 weeks * Unable or unwilling to return or be contacted for and/or complete research surveys * Currently incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline/screening * Individuals with latent infections who have an increased risk of infection.
About the study
The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.
What is being tested
- Dexamethasone (drug)
- Supportive Care (other)
Sponsor: University of Washington · Participants: 550 · Started: Feb 3, 2026
Contact the study team
- Kelsey Pullar, MPH · Phone: 206.221.8247
- Erin Fannon · Phone: 206.685.9770
Official record on ClinicalTrials.gov — NCT07084441
Locations in the U.S.
| New York | Columbia University Medical Center, New York |
| Washington | Harborview Medical Center, Seattle UW Medical Center - Northwest, Seattle University of Washington Medical Center Montlake, Seattle |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.