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Studying the Effects of Nicotine Concentration and Flavor on Alcohol Use in Young Adults

Assessing Co-Use of Oral Nicotine Pouches and Alcohol Among Young Adults

Who can join

Ages 21 to 30 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 21-30 years old
* Use ONPs daily
* Drink alcohol at least three days/week
* Read and speak English
* Own an iPhone (required for BACtrack Skyn wristband)
* Used 6 mg nicotine concentration ONPs on at least 20 days of past month

Exclusion Criteria:

* Use of other tobacco products \> 10 days/month
* Unstable or significant medical condition
* Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
* History of cardiac event or distress within the past three months
* Currently pregnant, planning to become pregnant within six months, or breastfeeding (all participants assigned female at birth will take a pregnancy test at each clinic visit before provision of study products; a negative test will be needed to proceed with product sampling)

About the study

This clinical trial studies the use of both (co-use) oral nicotine pouches (ONPs) and alcohol among young adults and whether ONP nicotine concentration and flavor affect alcohol use. The co-use of nicotine and alcohol has grown among young adults and the increase in ONP use among young adults may be a contributing factor. ONPs do not contain tobacco leaf and may reduce cancer risk for those who switch from traditional tobacco products (e.g., cigarettes, moist snuff) to ONPs. However, given that alcohol is a cancer-causing agent, using ONPs might increase alcohol use among young adults, which may cause an increase in their risk of cancer. ONPs come in different nicotine concentrations and flavors, with young adults expressing a preference in nicotine concentration or flavor for use while drinking. The different nicotine concentrations and flavors could lead users to drink more or longer. Studying the co-use of ONPs and alcohol among young adults may help researchers understand whether ONP nicotine concentrations and flavors affect alcohol use. This information may be used to help guide future ONP regulations and cancer prevention interventions targeted to young adults.

What is being tested

• Ecological Momentary Assessment (other)
• Monitoring (other)
• Nicotine Oral Pouch (drug)
• Survey Administration (other)

Sponsor: Ohio State University Comprehensive Cancer Center · Participants: 20 · Started: Sep 3, 2025

Contact the study team

• The Ohio State University Comprehensive Cancer Center · Phone: 800-293-5066

Official record on ClinicalTrials.gov — NCT07095140

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.