Nerve Excitability in Cisplatin-Induced Peripheral Neuropathy

Inclusion Criteria Cohort A:

* Adults age ≥ 18 who will begin cisplatin-based chemotherapy either alone or in combination with other agents that are not known to cause neuropathy.
* Participants must have adequate hematologic parameters to allow chemotherapy.

Exclusion Criteria Cohort A:

* Pre-existing peripheral neuropathy;
* Family history of a genetic/familial neuropathy;
* Any contraindication for treatment with cisplatin as determined by their primary oncologist;
* Chemotherapy regimen combining cisplatin with another known chemotherapy agent that may cause peripheral neuropathy;
* Patients with cardiac or spinal stimulating devices;
* Women who are pregnant or breastfeeding;
* Adults with impaired consent capacity as patients must be able to fill out questionnaires regarding their neuropathy symptoms;
* Other medical conditions that in the opinion of the treating physician would make the protocol unreasonably hazardous for the patient;
* Patients not considered to be able to comply with the protocol.

Inclusion Criteria Cohort B:

* Adults age ≥ 18 with a diagnosis of cis-PN.
* The last dose of cisplatin must be ≥ 3 months prior to study enrollment. Patients who may have been previously enrolled in Cohort A of this study are eligible to participate in Cohort B if they continue to have cis-PN symptoms 3 months after completion of cisplatin therapy.

Exclusion Criteria Cohort B:

* Pre-existing peripheral neuropathy;
* Family history of a genetic/familiar neuropathy;
* History of cisplatin-based regimen combining cisplatin with another known chemotherapy agent that may cause peripheral neuropathy;
* Patients with cardiac or spinal stimulating devices;
* Women who are pregnant or breastfeeding;
* Adults with impaired consent capacity as patients must be able to fill out questionnaires regarding their neuropathy symptoms;
* Other medical conditions that in the opinion of the treating physician would make the protocol unreasonably hazardous for the patient;
* Patients not considered to be able to comply with the protocol.