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Intracervical Vasopressin
Intracervical Vasopressin for Completion of Hysteroscopic Removal of Retained Products of Conception
Who can join
Ages 18 to 51 · Women
Full eligibility criteria
Inclusion Criteria: * Women * Aged 18-51 * Undergoing surgical management for retained products of conception, postpartum retained products of conception or 1st trimester missed or incomplete abortion Exclusion Criteria: * Hemodynamic instability * Active hemorrhage- soaking pad/hour * Allergy to vasopressin * Concern for intrauterine arteriovenous malformation * Inability to consent
About the study
This randomized study looks at whether using a medicine injected into the cervix of the uterus (intracervical), called vasopressin, helps to achieve better removal of retained products of conception (RPOC). RPOC means that after a pregnancy has ended (through miscarriage, abortion, or delivery), some parts of the pregnancy tissue, usually from the placenta or fetus, have stayed in the uterus. A hysteroscopic removal of RPOC is one type of treatment. This is a surgical procedure where a doctor uses a small camera attached to a thin tube (called a hysteroscope) to look inside the uterus.
The main goal of the study is :
• To add to the existing research through this study to see if the injection of intracervical vasopressin leads to improved completion rates of hysteroscopic management of RPOC.
Participants will:
• would be randomized to receive either vasopressin intracervical injection or a placebo injection (non-active saline) during your procedure. Information from the procedure will be collected from the participant's medical record.
What is being tested
- Intracervical injection of Vasopressin (drug)
- Intracervical Injection of saline (drug)
Sponsor: Prisma Health-Upstate · Participants: 50 · Started: Oct 30, 2025
Contact the study team
- Patti Parker, BSN · Phone: 864-455-1510
- Paul Miller, MD · Phone: 894-455-1600
Official record on ClinicalTrials.gov — NCT07102615
Locations in the U.S.
| South Carolina | The OB/GYN Center, Greenville |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.