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Genetic Study to Determine the Cause of Birth Defects in Newborns in Texas
MAGNET: Making Genomics Accessible For Newborns In Texas
Who can join
1 Day – 90 Days · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Undiagnosed infants from 0-90 days of age, with a diverse group of phenotypes and strongly suspected to have genetic disorders. Exclusion Criteria: * (1) abnormal noninvasive prenatal testing (NIPT) suggesting chromosomal abnormality; (2) abnormal amniocentesis results, (3) abnormal newborn screening indicating an inborn error of metabolism; (4) abnormal FISH results for aneuploidy (trisomy 18, 13, or monosomy X); (5) Down syndrome; (6) dysmorphic features in the absence of other congenital anomalies; (7) isolated birth defects such as myelomeningocele, cleft lip/palate, cardiac septal defects, isolated congenital diaphragmatic hernia, etc.; (8) birth defects due to known teratogens i.e., alcohol, Isotretinoin, etc.; (9) multiple congenital anomalies associated with maternal diabetes; (10) VACTERL association; and (11) hemodynamically unstable newborns needing transport for higher level of care.
About the study
The purpose of this study is to provide advanced genetic testing and virtual consultations for seriously ill newborns in hospitals in Texas with fewer resources, especially along the Texas-Mexico border. The researchers also want to know how well the virtual consultation tool, called Consultagene, works in these hospitals by gathering feedback from healthcare providers. Researchers will provide rapid whole genome sequencing (WGS) to 200 infants over a period of 5 years. Data will be collected via Consultagene, surveys, and qualitative interviews.
What is being tested
- Rapid whole genome sequencing (genetic)
Sponsor: Baylor College of Medicine · Participants: 410 · Started: Oct 28, 2025
Contact the study team
- Seema R Lalani, MD · Phone: 281-224-0600
Official record on ClinicalTrials.gov — NCT07102966
Locations in the U.S.
| Texas | Baylor College of Medicine, Houston |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.