Home › Weight Control › NCT07104539
Strength Training Response of Muscle in GLP-1 Users
Who can join
Ages 50 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age, 50y+ * Be taking GLP-1 medicine (Weygovy or Zepbound) for 1 month or less * Weight \<300 lb * Pass a health and exercise readiness screening Exclusion Criteria: * Age \<50 * Weight \>300 lb * Osteoporosis * Active metabolic, neoplastic, or cardiovascular disease * Unable or unwilling to provide consent
About the study
GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance/fall risk among adults age 50 and older.
What is being tested
- Strength Training (behavioral)
- Wait first, then strength training (other)
Sponsor: Virginia Polytechnic Institute and State University · Participants: 30 · Started: Oct 8, 2025
Contact the study team
- Kevin Davy · Phone: 540-231-3487
- Elaina Marinik · Phone: 540-231-0923
Official record on ClinicalTrials.gov — NCT07104539
Locations in the U.S.
| Virginia | Virginia Tech, Blacksburg |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.