Home › NCT07110688

Novel Multimodal Neural, Physiological, and Behavioral Sensing and Machine Learning for Mental States

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

For the healthy population, all subjects over the age of 18 who are able and willing to give informed consent will be eligible.

For the epilepsy population, inclusion criteria are:

* Patients who suffer from drug-resistant epilepsy and already have intracranial EEG (iEEG) electrodes implanted based on clinical criteria for their standard seizure localization (unrelated to our study) will be eligible. Most patients are healthy adults outside of their epilepsy.
* Subjects \>= 18 are only included in this study.
* All patients with the above conditions and with already-implanted electrodes who are willing to participate and able to cooperate and follow research instructions will be recruited.

About the study

In this program, the investigators will develop novel multimodal neural-behavioral-physiological monitoring tools (software and hardware), and machine learning models for mental states within social processes and beyond. The tools consist of a multimodal skin-like wearable sensor for physiological and biochemical sensing; a conversational virtual human platform to evoke naturalistic social processes; audiovisual affect recognition software; synchronization tools; and machine learning methods to model the multimodal data. The investigators will demonstrate the tools in healthy subjects without neural recordings and in patients with drug-resistant epilepsy who already have intracranial EEG (iEEG) electrodes implanted based on clinical criteria for standard monitoring to localize seizures, which is unrelated to our study.

What is being tested

• Virtual human social interaction (behavioral)
• Cold pressor test (behavioral)

Sponsor: University of Southern California · Participants: 90 · Started: Aug 1, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT07110688

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.