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Non-Invasive ICP Monitoring Study

Non-Invasive Intracranial Pressure Waveform Dynamics

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adult patients (age \>18) undergoing craniotomy for any indication requiring hyperosmolar agents as a part of their surgery
* Adult patients (age \>18) in the neuro-oncology or neurosurgery clinic who are receiving diagnostic/therapeutic lumbar puncture as a part of their ordinary care
* Adult patients (age \>18) in the neurosurgery clinic with ventriculo-peritoneal shunts who require adjustments to increase or decrease drainage of cerebrospinal fluid.

Exclusion Criteria:

* Age \<18
* Lacking capacity to provide informed consent on their own behalf

About the study

Measuring the pressure inside the skull, which is called intracranial pressure, is important to treat severe neurological illness. Currently, measuring intracranial pressure requires doctors to place an invasive pressure monitor. Recently, a non-invasive intracranial pressure monitor has been developed. This monitor has a tiny pin that is placed on the head which measures the tiny movements of the skull every time the heart beats. This produces a waveform that looks very similar to an invasive intracranial pressure waveform. However, we don't know enough about how the non-invasive device to make it clinically useful yet.

What is being tested

• Brain4Care (device)

Sponsor: University of Texas Southwestern Medical Center · Participants: 30 · Started: Apr 10, 2026

Contact the study team

• Noah Jouett, DO, PhD · Phone: 214-633-3911

Official record on ClinicalTrials.gov — NCT07113353

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.