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Optimal Ventilation for Cardiac Arrest

OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes (OPTI-VENT)

Who can join

37 Weeks – 18 Years · All sexes

Inclusion Criteria:

* Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
* Received at least 1 minute of CPR.

Exclusion Criteria:

* Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care.
* Brain death determination prior to the CPR event.
* Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes).
* Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

About the study

Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.

What is being tested

• OPTI-VENT Bundle (other)
• Transition (other)
• None - control (other)

Sponsor: Children's Hospital of Philadelphia · Participants: 1,530 · Started: Oct 1, 2025

Contact the study team

• CHOP RSC Clinical Research Program Manager · Phone: 215-590-1859

Official record on ClinicalTrials.gov — NCT07114510

Locations in the U.S.

Conditions

• Sudden Cardiac Arrest

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.