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Definitive Radiation Therapy for Inoperable Breast Cancer
Multi-institutional Prospective Pilot Study of Definitive Breast Radiation Therapy for Invasive Breast Cancer Patients Not Undergoing Definitive Surgery
Who can join
Ages 18 and older · Women
Full eligibility criteria
Inclusion Criteria: * Biopsy proven invasive carcinoma of the breast, either lobular, ductal and/or no special type * T1-T4, N0-2, M0-1 invasive breast carcinoma by radiological or clinical criteria * Cancer is deemed unresectable, or the patient is a poor surgical candidate as determined following evaluation by a surgeon, or patient declines surgery. * Life expectancy \> 6 months * Negative pregnancy test at the time of start of treatment in any female of reproductive age Exclusion Criteria: * Concurrent systemic therapy (except for endocrine therapy, HER2-targeted therapy, or immunotherapy which are permitted) * Prior radiation to ipsilateral breast or regional nodes * Inability to receive study treatment planning and treatment secondary to body habitus
About the study
The purpose of this study is to find out if adding radiation therapy to routine medications for breast cancer helps in reducing and preventing the cancer from getting worse. Patients with a locally advanced breast cancer who cannot, or do not want to, undergo surgery are eligible to participate. Participation in this study does not prevent you from undergoing surgery in the future.
What is being tested
- Whole breast radiation with simultaneous integrated boost (WB-SIB) to primary breast tumor (radiation)
- Whole breast radiation with simultaneous integrated boost (WB-SIB) to primary breast tumor and ipsilateral axillary lymph nodes (radiation)
Sponsor: Alexander Stessin · Participants: 30 · Started: Dec 8, 2025
Contact the study team
- Caterina Stony Brook Cancer Center Clinical Trials · Phone: 631-728-7425
- Caterina Vacchi-Suzzi, PhD · Phone: 6312162993
Official record on ClinicalTrials.gov — NCT07122713
Locations in the U.S.
| New York | Stony Brook University Cancer Center, Stony Brook |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.