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Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy
Reducing Spontaneous Recovery Using Functional Connectivity Based Real-time Functional Magnetic Resonance Imaging Neurofeedback Targeting the Memory Control Network
Who can join
Ages 18 to 50 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Adults aged 18-50 * No history of psychiatric disorders or neurological disorders affecting the central nervous system. * Are not currently taking psychoactive medication or drugs of abuse. * Must be eligible to enter an MRI (i.e., no permanent metal or medical implants) * Normal color vision * Right-handed * Full reading and writing English comprehension * Must exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session * Must be able to provide informed consent Exclusion Criteria: * Pregnancy (female participants) * Outside of age range * History of psychiatric or neurological disease * Currently taking psychoactive medication or drugs of abuse * Color blindness * Primary left-handedness * Less than full reading and writing English comprehension * Do not exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session * Refusing to provide informed consent
About the study
This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults. This real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention delivers feedback based on a functional connection between the prefrontal cortex and the hippocampus.
What is being tested
- Active Real-time fMRI Neurofeedback (behavioral)
- Sham Real-time fMRI neurofeedback (behavioral)
Sponsor: Trustees of Princeton University · Participants: 40 · Started: Jul 17, 2025
Contact the study team
- Augustin C. Hennings, Ph.D. · Phone: 609-258-5032
Official record on ClinicalTrials.gov — NCT07122739
Locations in the U.S.
| New Jersey | Princeton Neuroscience Institute, Princeton |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.