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A Study to Learn About a Vaccine Against E Coli in Healthy Adults

RecruitingPhase 1Healthy volunteers welcome

A PHASE 1, RANDOMIZED, DOUBLE-BLIND, THIRD-PARTY-UNBLINDED STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF A VACCINE AGAINST E COLI IN HEALTHY ADULTS

Who can join

Ages 18 to 64 · All sexes · Healthy volunteers welcome

Full eligibility criteria

Ages Eligible for Study: 18 to 64 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes

Key Inclusion Criteria

1. Adult Participants \>= 18 through \< 64 years of age at the time of enrollment.
2. Healthy participants as determined by medical history, physical examination, and clinical judgement of the investigator to be eligible for inclusion in the study.

Key Exclusion Criteria

1. Severe adverse reaction history associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s).
2. Immunocompromised individuals with known or suspected immunodeficiency, as determined by history and/or laboratory/physical examination.
3. Women who are pregnant, plan to become pregnant during the study, or are breastfeeding.

About the study

This study evaluates an investigational vaccine designed to protect against Escherichia coli (E coli). The primary objective is to assess the safety and tolerability of E coli vaccines administered intramuscularly to healthy adults.

What is being tested

E coli vaccine 1 Dose A (drug)
E coli vaccine 1 Dose B (drug)
E coli vaccine 2 (drug)
E coli vaccine 3 (drug)
E coli Vaccine 4 Dose A (drug)
E coli Vaccine 4 Dose B (drug)

Sponsor: Pfizer · Participants: 310 · Started: Aug 11, 2025

Contact the study team

Pfizer CT.gov Call Center · Phone: 1-800-718-1021

Official record on ClinicalTrials.gov — NCT07122986

Locations in the U.S.

California	Anaheim Clinical Trials, LLC, Anaheim Orange County Research Center, Lake Forest Diablo Clinical Research, Inc., Walnut Creek
Florida	Miami Eye Institute, Hollywood Research Centers of America, Hollywood
New York	NYU Langone Health, New York
Ohio	CTI Clinical Research Center, Cincinnati Senders Pediatrics, South Euclid
Tennessee	Alliance for Multispecialty Research, LLC, Knoxville Alliance for Multispecialty Research, LLC, Knoxville University Eye Specialists, P.C. (Ophthalmologist), Maryville

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.