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Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor

Parenteral Lactated Ringer's Plus Dextrose 5% vs Lactated Ringer's in Labor: A Randomized Control Trial on Maternal and Neonatal Outcomes

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Nulliparous women
* Age 18 years or older and able to provide informed consent
* Singleton pregnancy at term
* Induction of labor
* Cephalic presentation
* Unfavorable cervix (Bishop score ≤ 6)

Exclusion Criteria:

* Age under 18 years
* Involuntarily confined or detained
* Considered as having diminished decision-making capacity
* Spontaneous labor (cervical exam between 5-6 cm) with or without ruptured membraned
* Favorable cervix (Bishop score \>6)
* Diabetes mellitus (both gestational and pre-gestational)
* Structural renal disease
* Acute or chronic kidney disease resulting in abnormal creatinine or proteinuria
* Evidence of chorioamnionitis or non-reassuring fetal testing at the time of enrollment
* Pyrexia (\>38.0 degrees Celsius)
* Stillbirth
* Planned cesarean delivery
* Women presenting with emergent circumstances for labor induction

About the study

The goal of this clinical trial is to determine which of two types of standard intravenous (IV) fluids (a combination of 5% dextrose and Lactated Ringers solution and Lactated Ringers solution alone) has a better influence on labor when inducing labor in pregnant women. The main questions it aims to answer are:

1. Does the use of 5% dextrose and Lactated Ringers lead to a shorter labor than the use of just Lactated Ringers? 2. Does the use of 5% dextrose and Lactated Ringers increase the risk of neonatal hypoglycemia when compared to Lactated Ringers? Participants in this trial will be randomly assigned to one of two groups: a group that receives a solution of 5% dextrose and Lactated Ringers, and a group that receives Lactated Ringers alone. Researchers will compare the outcomes of the two groups to see which IV fluid is more effective.

What is being tested

• 5% Dextrose (D5) in Normal Saline (NS) (drug)
• Lactate Ringer (drug)

Sponsor: Eastern Virginia Medical School · Participants: 158 · Started: 2025-09

Contact the study team

• Tetsuya Kawakita, MD · Phone: 757-446-7900

Official record on ClinicalTrials.gov — NCT07124130

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.