Acute Effects of Oral Nicotine Pouches

Inclusion criteria (all participants):

* greater than or equal to 21 years old
* good general health based on screening procedures
* vital signs in normal range (resting heart rate less than 110bpm, systolic blood pressure less than 150mmHg, diastolic blood pressure less than 100mmHg)
* negative urine test for illicit drug use (excluding THC) and negative breath alcohol test at screening and before each session
* no self-reported prior use of oral nicotine pouches
* Not actively trying to quit smoking or using smoking cessation medication (e.g., nicotine replacement therapy)

Additional inclusion criteria (smokers):

* self-report currently smoking cigarettes daily
* exhaled breath CO greater than or equal to 10ppm and urine cotinine greater than 100 ng/ml at screening
* meet criteria for tobacco use disorder
* no self-reported regular use of other tobacco products (e.g., smokeless products, e-cigarettes) in the past 30 days

Additional inclusion criteria (non-nicotine users):

* self-report previously using nicotine/tobacco but no more than 100 lifetime uses across all routes of administration
* no self-reported nicotine/tobacco uses in the past 30 days
* urine cotinine less than 100 ng/ml at screening.

Exclusion criteria (all participants):

* psychoactive drug use (aside from cannabis, nicotine, alcohol, or caffeine) in past month
* current use of OTC drugs, supplements/vitamins, or prescription medications that, in the opinion of medical staff, will impact safety
* currently have severe dependence for cannabis
* history of or current significant medical condition that, in the opinion of medical staff, will impact safety
* current psychiatric condition or substance use disorder (aside from tobacco use disorder for smokers), that, in the opinion of medical staff, will impact safety
* women who are pregnant, planning to become pregnant, or are breast-feeding