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Optimizing Liver MRI Using Breath-Holding With and Without Oxygen

Optimizing MRI Liver Imaging: Evaluating Breath-Holding Techniques and Oxygen Supplementation to Reduce Respiratory Motion Artifacts

Who can join

Ages 18 to 75 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Subject must be within 18-75 years of age;
* Subject must be able to hear and understand instructions without assistive devices;
* Subject must provide written informed consent;
* Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements;
* Subject is able to remain still for duration of imaging procedure (approximately 30-45 minutes)

Exclusion Criteria:

* Subjects with a weight greater than 499 lbs;
* Subjects that have metallic/conductive or electrically/magnetically active implants without Magnetic Resonance (MR) Safe or Magnetic Resonance (MR) Conditional labeling, with the exception of dental devices/fillings, surgical clips, and surgical staples determined to be safe for MRI scanning by a physician investigator;
* Subjects that have implants with MR Unsafe labeling;
* Subjects that have implants labeled as MR Conditional by the manufacturer for which the allowable conditions are not expected to be achieved by the MR environment or scan protocol;
* Subjects who have a contraindication to MRI per the screening policy of the participating site;
* Subjects with any respiratory or cardiovascular condition that could compromise safe breath holding;
* Subjects who are female and pregnant

About the study

The goal of this interventional study (clinical trial) is to learn if different breath-holding techniques, with and without extra oxygen, can improve the quality of abdominal Magnetic Resonance Imaging (MRI) images in healthy adults, ages 18-75.

The main questions it aims to answer are:

* Does breath-holding at end-expiration improve image quality in abdominal MRI scans? * Does adding oxygen while breath-holding further reduce motion artifacts in abdominal MRI scans?

Researchers will compare breath-holding with and without oxygen to see if using oxygen improves image quality during MRI scans.

Participants will:

* Be pre-screened for MRI safety and trained on breath-hold procedures * Have one non-contrast abdominal MRI scan at the University of California San Francisco (UCSF) China Basin Imaging Center * Use two different breath-holding techniques during the scan, with and without oxygen * Complete one study visit lasting about 45 minutes to 1 hour

What is being tested

• Breath-hold conditions (other)

Sponsor: University of California, San Francisco · Participants: 10 · Started: Dec 1, 2025

Contact the study team

• John P Roberts, MD · Phone: 415-353-3677

Official record on ClinicalTrials.gov — NCT07135401

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.