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A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* 18 years of age or older
* LDL-C \>170 mg/dL in response to starting a ketogenic diet

Exclusion Criteria:

* Patients who do not consent to blood draw for genetic testing
* Those with LDL-C \<170 mg/dL on a ketogenic diet

About the study

The purpose of this study is to identify whether individuals following a ketogenic diet who experience extreme LDL-C elevation, termed "hyper-responders", have identifiable genetic variations in genes involved in cholesterol absorption.

Sponsor: Mayo Clinic · Participants: 100 · Started: Sep 11, 2025

Contact the study team

• Saad Omar · Phone: 507-538-5162

Official record on ClinicalTrials.gov — NCT07137286

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.