Home › Cancer (all types) › NCT07138040

Re-Engaging AYA Survivors in Cancer-Related Healthcare

Re-Engaging AYA Survivors in Cancer-Related Healthcare: A Sequential Multiple Assignment Randomized Trial

Who can join

Ages 15 to 29 · All sexes

Inclusion Criteria for AYA

1. 15-29 years old
2. History of a childhood cancer diagnosis, diagnosed prior to age 22
3. Has not had a cancer-related follow-up visit in at least 15 months (or is 3 months past recommended follow-up)
4. U.S. resident (not international patient)
5. Has previously attended a cancer-related appointment at Children's Hospital of Philadelphia, or Nationwide Children's Hospital or Penn
6. At least 2 years from end of treatment and 5 years from diagnosis
7. English proficient
8. For AYA under age 18, must have a caregiver to provide informed consent

Exclusion Criteria for AYA

1. Cognitive impairment limiting participation
2. Received surgery only treatment
3. Transferred to primary care
4. Currently living with cancer diagnosis (either new, metastatic, recurrence, or relapse)
5. Absence of documentation of treatment history
6. Absence of inclusion criteria above

Inclusion Criteria for Support Person of AYA

1. Primary caregiver or other support person (e.g. partner, sibling, other caregiver)
2. At least 18 years old
3. U.S. resident
4. English proficient

Exclusion Criteria for Support Person of AYA

1. No involvement in the AYA's healthcare
2. AYA Decline support person's participation
3. Absence of inclusion criteria above

About the study

The goal of this clinical trial is to test the efficacy (how well they work) of different digital interventions that deliver information to adolescent and young adult (AYA) survivors of childhood cancer to promote re-engagement in cancer-related long-term follow-up care (LTFU). The main aims are:

* To test the efficacy of adaptive interventions (AIs) that begin with low touch intervention (LTI) as compared to written information (WI) on attending an appointment, and self-reported self-management among AYA. * To identify the most efficacious second-stage strategy for those who initially schedule/attend an appointment (maintenance vs. step-up) and for those who do not (step-up vs. step-up maximum). * To assess multilevel factors contributing to the effects of re-engaging AYA and how best to integrate AIs into practice.

Throughout the duration of the study, participants will complete four surveys, receive a series of interventions, and may be asked to participate in an interview (post-intervention).

What is being tested

• Stage 1 Written Information (behavioral)
• Stage 1 Low Touch Intervention (behavioral)
• Stage 2 Written Information (behavioral)
• Stage 2 Low Touch Intervention (behavioral)
• Stage 2 High Touch Intervention (behavioral)

Sponsor: Children's Hospital of Philadelphia · Participants: 530 · Started: Aug 1, 2025

Contact the study team

• Lisa Schwartz, PhD · Phone: (267) 426-0355
• Sara King-Dowling, PhD · Phone: (267) 426-5562

Official record on ClinicalTrials.gov — NCT07138040

Locations in the U.S.

Conditions

• Cancer (all types)

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.