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Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers

RecruitingObservational study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Eligibility Criteria

1. Participants scheduled to undergo ultrasound-guided RFA for the following conditions: benign thyroid nodules, indeterminate thyroid nodules, low-risk DTC, and recurrent PTC
2. Participant is over 18 years and is either not a surgical candidate or has declined surgery.
3. Capable and willing to provide written informed consent
4. Participant has one of the following diagnoses:

   * Biopsy-proven benign thyroid nodules causing compressive and/or cosmetic symptoms who are requesting treatment,
   * Biopsy-proven indeterminate nodules (AUS or follicular neoplasm)
   * Papillary thyroid carcinoma (PTC) without metastasis
   * Locally recurrent thyroid cancer (\< 2 cm).

Exclusion Criteria

1. Participants meeting any of the following criteria will be excluded:
2. Participants considered unsuitable for RFA by the treating physician

About the study

To track the outcomes of patients who have been treated with RFA and its long-term effectiveness, and to learn more about the quality of life of patients who have received RFA in this study.

What is being tested

Sponsor: M.D. Anderson Cancer Center · Participants: 50 · Started: Aug 18, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07140757

Locations in the U.S.

TexasMD Anderson Cancer Center, Houston

Conditions

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.