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Effect of Local Anesthetic Concentration on Rebound Pain
RecruitingPhase 4
Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Total shoulder replacement patients (anatomic and reverse) * Adult patients (greater than or equal to 18 years) * Any gender * Any race Exclusion Criteria: * \- Chronic Pain diagnoses including: * substance/opioid use disorder * complex regional pain syndromes * fibromyalgia * Daily persistent opioid use spanning 3 months prior to surgery date * Allergy to local anesthetics or NSAIDS * Respiratory pathologies including: * CPAP- non-compliant / untreated obstructive sleep apnea * COPD * Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc) * Contralateral diaphragm dysfunction * BMI \> 40 * Ipsilateral extremity pre-existing nerve injury * GFR \< 60 * NSAID contraindications * Inability to follow up * Revision surgery * Patients requesting block as primary (avoidance of general anesthesia) * Need or request for brachial plexus catheter or liposomal bupivacaine * Vulnerable populations (pregnancy, incarceration, etc) * non-English speaking
About the study
Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.
What is being tested
- Bupivacaine (drug)
Sponsor: University of Virginia · Participants: 10 · Started: May 13, 2026
Contact the study team
- Leon N Grinman, DO · Phone: 434-924-3627
- Brett Elmore, MD · Phone: 434-924-3627
Official record on ClinicalTrials.gov — NCT07146685
Locations in the U.S.
| Virginia | UVA Health, Charlottesville |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.